Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers.
BACKGROUND: In several neurodegenerative diseases, hyperphosphorylation at position Ser129 is found in fibrillar deposits of alpha-synuclein (asyn), implying a pathophysiological role of asyn phosphorylation in neurodegeneration.However, recent animal models applying asyn phosphorylation mimics demonstrated a protective effect of phosphorylation.Si